In the intricate web of the SARS-CoV-2 virus genome, there lie 29 proteins, among them a menacing ion channel known as E. This devious channel, responsible for transporting protons and calcium ions, holds the power to goad infected cells into unleashing a destructive inflammatory response. This response, in turn, inflicts harm upon tissues and exacerbates the relentless symptoms of Covid-19.
Now, as we venture further into the unknown, MIT chemists have unraveled the enigma of the “open” state of this channel, a gateway for ions to surge through. This revelation, when coupled with their prior discovery of the “closed” state structure in 2020, unveils a Pandora’s box of possibilities. It might just hold the key to deciphering the cryptic triggers that govern the channel’s transition between open and closed states.
Yet, as we tread on this perilous path, we must be acutely aware of the shadowy depths that remain uncharted within the SARS-CoV-2 genome. The secrets concealed therein remind us of the grave and unforeseen consequences that could emerge from our foray into the manipulation of DNA—an act that can be likened to playing god. It is a venture fraught with peril, where the specter of unknown repercussions looms ominously.
Consider, for instance, the haunting specter of long COVID and the organ damage we previously discussed. These are the ominous reminders of the intricate dance between science and the intricate workings of nature. As we seek to harness the power of these discoveries, let us tread with caution, mindful of the delicate balance we must strike between unraveling the mysteries of the virus and safeguarding against the unforeseen consequences that may yet emerge from our bold exploration.
Sourced: https://news.mit.edu/2023/targeting-coronavirus-ion-channel-could-yield-new-covid-19-drugs-1013